Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Famotidine Calmicid Increased risk of QT interval prolongation Details Levofloxacin Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Levofloxacin Felbamate Felbatol Increased risk of QT interval prolongation Details Levofloxacin Flecainide Tambocor® Increased risk of QT interval prolongation Details Levofloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Levofloxacin Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Levofloxacin Fostemsavir Rukobia Increased risk of torsade de pointes Details Levofloxacin Galantamine Razadyne Increased risk of QT interval prolongation Details Levofloxacin Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Levofloxacin Gemifloxacin Factive Increased risk of QT interval prolongation Details Levofloxacin Glasdegib Daurismo Increased risk of QT interval prolongation Details Levofloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Levofloxacin Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Levofloxacin Granisetron Injection Granisol Increased risk of QT interval prolongation Details Levofloxacin Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Levofloxacin Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Levofloxacin Hydrocortisone Injection A-Hydrocort® An increased risk of tendon rupture Details Levofloxacin Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Levofloxacin Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Levofloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Ivabradine Corlanor Increased risk of QT prolongation Details Levofloxacin Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Levofloxacin Lefamulin Xenleta Increased risk of QT interval prolongation Details Levofloxacin Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Levofloxacin Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Acenocoumarol Increased INR Details Levofloxacin Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Levofloxacin Albiglutide Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Levofloxacin Apomorphine Apokyn Increased risk of QT interval prolongation Details Levofloxacin Aripiprazole Abilify An increased risk of QT interval prolongation Details Levofloxacin Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Levofloxacin Artemether An increased risk of QT interval prolongation Details Levofloxacin Asenapine Saphris Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.