Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Moderate

Levofloxacin Droxicam An increased risk of seizures Details Levofloxacin Etofenamate An increased risk of seizures Details Levofloxacin Etoricoxib An increased risk of seizures Details Levofloxacin Felbinac An increased risk of seizures Details Levofloxacin Fepradinol An increased risk of seizures Details Levofloxacin Feprazone An increased risk of seizures Details Levofloxacin Floctafenine An increased risk of seizures Details Levofloxacin Flufenamic Acid An increased risk of seizures Details Levofloxacin Ibuprofen Lysine An increased risk of seizures Details Levofloxacin Indomethacin Indocin An increased risk of seizures Details Levofloxacin Iron Decreased levofloxacin effectiveness Details Levofloxacin Lanthanum Carbonate Fosrenol Reduced bioavailability of quinolone antibiotics Details Levofloxacin Lornoxicam An increased risk of seizures Details Levofloxacin Loxoprofen An increased risk of seizures Details Levofloxacin Lumiracoxib An increased risk of seizures Details Levofloxacin Magaldrate Decreased oral levofloxacin effectiveness Details Levofloxacin Magnesium Carbonate Decreased oral levofloxacin effectiveness Details Levofloxacin Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased oral levofloxacin effectiveness Details Levofloxacin Magnesium Oxide Mag-Ox 400 Decreased oral levofloxacin effectiveness Details Levofloxacin Magnesium Trisilicate Decreased oral levofloxacin effectiveness Details Levofloxacin Meclofenamate Meclodium® An increased risk of seizures Details Levofloxacin Mefenamic Acid Ponstel® An increased risk of seizures Details Levofloxacin Meloxicam Alloxate An increased risk of seizures Details Levofloxacin Morniflumate An increased risk of seizures Details Levofloxacin Nabumetone Relafen An increased risk of seizures Details Levofloxacin Naproxen Aleve An increased risk of seizures Details Levofloxacin Nepafenac Ilevro An increased risk of seizures Details Levofloxacin Niflumic Acid An increased risk of seizures Details Levofloxacin Nimesulide An increased risk of seizures Details Levofloxacin Nimesulide Beta Cyclodextrin An increased risk of seizures Details Levofloxacin Oxaprozin Coxanto An increased risk of seizures Details Levofloxacin Oxyphenbutazone An increased risk of seizures Details Levofloxacin Parecoxib An increased risk of seizures Details Levofloxacin Phenylbutazone Equi-Phar An increased risk of seizures Details Levofloxacin Phenytoin Dilantin Decrease in phenytoin levels Details Levofloxacin Piketoprofen An increased risk of seizures Details Levofloxacin Piroxicam Feldene An increased risk of seizures Details Levofloxacin Proglumetacin An increased risk of seizures Details Levofloxacin Propionic Acid An increased risk of seizures Details Levofloxacin Propyphenazone An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.