Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Astemizole Increased risk of QT interval prolongation Details Levofloxacin Atazanavir Reyataz Increased risk of QT interval prolongation Details Levofloxacin Betamethasone Betavet An increased risk of tendon rupture Details Levofloxacin Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Bupropion Aplenzin Increased risk of seizures Details Levofloxacin Ceritinib Zykadia An increased risk of QT interval prolongation Details Levofloxacin Chlorpromazine Increased risk of QT interval prolongation Details Levofloxacin Chlorpropamide Diabinese® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Levofloxacin Ciprofloxacin Increased risk of QT interval prolongation Details Levofloxacin Citalopram Celexa An increased risk of QT interval prolongation Details Levofloxacin Clarithromycin Biaxin Increased risk of QT interval prolongation Details Levofloxacin Clofazimine An increased risk of QT interval prolongation Details Levofloxacin Clomipramine Anafranil An increased risk of QT interval prolongation and an increased risk of seizures Details Levofloxacin Clothiapine Increased risk of cardiac arrhythmias Details Levofloxacin Clozapine Clozaril Increased risk of QT interval prolongation Details Levofloxacin Corticotropin An increased risk of tendon rupture Details Levofloxacin Cortisone An increased risk of tendon rupture Details Levofloxacin Cosyntropin An increased risk of tendon rupture Details Levofloxacin Crizotinib Xalkori An increased risk of QT interval prolongation Details Levofloxacin Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Levofloxacin Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Levofloxacin Degarelix Firmagon Increased risk of QT interval prolongation Details Levofloxacin Delamanid Increased risk of QT interval prolongation Details Levofloxacin Desflurane Suprane An increased risk of QT interval prolongation Details Levofloxacin Desipramine Norpramin Increased risk of QT interval prolongation Details Levofloxacin Dexamethasone An increased risk of tendon rupture Details Levofloxacin Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Levofloxacin Domperidone Increased risk of QT interval prolongation Details Levofloxacin Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Levofloxacin Dordaviprone An increased risk of QT interval prolongation Details Levofloxacin Doxepin Prudoxin Increased risk of QT interval prolongation Details Levofloxacin Droperidol Increased risk of QT interval prolongation Details Levofloxacin Dulaglutide Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Ebastine Increased risk of QT interval prolongation Details Levofloxacin Efavirenz An increased risk of QT interval prolongation Details Levofloxacin Eribulin Halaven Increased risk of QT interval prolongation Details Levofloxacin Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Levofloxacin Escitalopram Lexapro An increased risk of QT interval prolongation Details Levofloxacin Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.