Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Exenatide Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Fexinidazole An increased risk of QT interval prolongation Details Levofloxacin Fingolimod Gilenya Increased risk of QT interval prolongation Details Levofloxacin Fluconazole Diflucan Increased risk of QT interval prolongation Details Levofloxacin Fludrocortisone An increased risk of tendon rupture Details Levofloxacin Fluocortolone An increased risk of tendon rupture Details Levofloxacin Fluoxetine RECONCILE An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Levofloxacin Formoterol Perforomist Increased risk of QT interval prolongation Details Levofloxacin Foscarnet Foscavir Increased risk of QT interval prolongation Details Levofloxacin Fosfomycin Contepo An increased risk of QT interval prolongation Details Levofloxacin Fosphenytoin Cerebyx Increased risk of QT interval prolongation Details Levofloxacin Gatifloxacin Zymaxid Increased risk of QT interval prolongation Details Levofloxacin Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Levofloxacin Gepotidacin Blujepa An increased risk of QT interval prolongation Details Levofloxacin Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Glyburide DiaBeta® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Goserelin Increased risk of QT interval prolongation Details Levofloxacin Granisetron Increased risk of QT interval prolongation Details Levofloxacin Halofantrine Increased risk of QT interval prolongation Details Levofloxacin Haloperidol Increased risk of QT interval prolongation Details Levofloxacin Histrelin Supprelin Increased risk of QT interval prolongation Details Levofloxacin Hydroquinidine Increased risk of QT interval prolongation Details Levofloxacin Hydroxyzine An increased risk of QT interval prolongation Details Levofloxacin Ibutilide Corvert An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Iloperidone Fanapt Increased risk of QT interval prolongation Details Levofloxacin Imipramine Increased risk of QT interval prolongation Details Levofloxacin Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Levofloxacin Insulin Afrezza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Aspart, Recombinant Fiasp Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Bovine Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Degludec Tresiba Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Detemir Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Glulisine Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Insulin Lispro, Recombinant Admelog Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Itraconazole Sporanox Increased risk of QT interval prolongation Details Levofloxacin Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Levofloxacin Ketoconazole Extina Increased risk of QT interval prolongation Details Levofloxacin Lapatinib Tykerb Increased risk of QT interval prolongation Details Levofloxacin Leuprolide Eligard Increased risk of QT interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.