Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Liraglutide Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Lixisenatide Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Levofloxacin Lofexidine Increased risk of QT interval prolongation Details Levofloxacin Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Levofloxacin Lumefantrine Increased risk of QT interval prolongation Details Levofloxacin Macimorelin Increased risk of QT interval prolongation Details Levofloxacin Magnesium Sulfate May reduce absorption of fluoroquinolone antibiotics Details Levofloxacin Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Mefloquine Lariam® Increased risk of QT interval prolongation Details Levofloxacin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Levofloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Methadone Diskets Increased risk of QT interval prolongation Details Levofloxacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Levofloxacin Methylprednisolone Depo-Medrol An increased risk of tendon rupture Details Levofloxacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Levofloxacin Mifepristone Korlym Increased risk of QT interval prolongation Details Levofloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Milsaperidone An increased risk of QT interval prolongation Details Levofloxacin Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Levofloxacin Mizolastine Increased risk of QT interval prolongation Details Levofloxacin Mobocertinib Exkivity An increased risk of QT interval prolongation Details Levofloxacin Moricizine Increased risk of QT interval prolongation Details Levofloxacin Moxifloxacin Avelox Increased risk of QT interval prolongation Details Levofloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Nelfinavir Viracept Increased risk of QT interval prolongation Details Levofloxacin Nilotinib Increased risk of QT interval prolongation Details Levofloxacin Norfloxacin Increased risk of QT interval prolongation Details Levofloxacin Octreotide Bynfezia Increased risk of QT interval prolongation Details Levofloxacin Ofloxacin Floxin® Increased risk of QT interval prolongation Details Levofloxacin Olanzapine Increased risk of QT interval prolongation Details Levofloxacin Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Levofloxacin Ondansetron An increased risk of QT interval prolongation Details Levofloxacin Osilodrostat Isturisa Increased risk of QT interval prolongation Details Levofloxacin Osimertinib Tagrisso Increased risk of QT interval prolongation Details Levofloxacin Oxaliplatin Increased risk of QT-interval prolongation Details Levofloxacin Ozanimod Additive effects on heart rate Details Levofloxacin Pacritinib Vonjo® An increased risk of QT interval prolongation Details Levofloxacin Paliperidone Erzofri Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.