Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Panobinostat Farydak Increased risk of QT interval prolongation Details Levofloxacin Paroxetine Paxil Increased risk of QT interval prolongation Details Levofloxacin Pasireotide Signifor Increased risk of QT prolongation Details Levofloxacin Pazopanib Votrient Increased risk of QT interval prolongation Details Levofloxacin Pentamidine NebuPent Increased risk of QT interval prolongation Details Levofloxacin Perphenazine Increased risk of QT interval prolongation Details Levofloxacin Phenobarbital Fidoquel An increased risk of QT interval prolongation Details Levofloxacin Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Levofloxacin Pioglitazone Actos Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Pipamperone Increased risk of QT interval prolongation Details Levofloxacin Pitolisant Wakix Increased risk of QT interval prolongation Details Levofloxacin Ponesimod Ponvory An increased risk of QT interval prolongation Details Levofloxacin Porfimer Excessive intracellular damage in photosensitized tissues Details Levofloxacin Posaconazole Noxafil Increased risk of QT interval prolongation Details Levofloxacin Pramlintide Symlin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Prednisolone Flo-Pred® An increased risk of tendon rupture Details Levofloxacin Prednisone Deltasone An increased risk of tendon rupture Details Levofloxacin Primidone Mysoline An increased risk of QT interval prolongation Details Levofloxacin Probucol Increased risk of QT interval prolongation Details Levofloxacin Procainamide Procan® Increased risk of QT interval prolongation Details Levofloxacin Prochlorperazine Increased risk of QT interval prolongation Details Levofloxacin Promethazine Phenadoz Increased risk of QT interval prolongation Details Levofloxacin Propafenone Rythmol Increased risk of QT interval prolongation Details Levofloxacin Protriptyline Increased risk of QT interval prolongation Details Levofloxacin Quetiapine Seroquel An increased risk of QT interval prolongation Details Levofloxacin Quinidine Cardioquin® Increased risk of QT interval prolongation Details Levofloxacin Quinine Increased risk of QT interval prolongation Details Levofloxacin Quizartinib Vanflyta An increased risk of QT interval prolongation Details Levofloxacin Ranolazine Aspruzyo Increased risk of QT interval prolongation Details Levofloxacin Rasagiline Azilect Increased rasagiline exposure Details Levofloxacin Repaglinide Prandin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Revumenib Revuforj An increased risk of QT interval prolongation Details Levofloxacin Ribociclib Kisqali An increased risk of QT interval prolongation Details Levofloxacin Rilpivirine Edurant Increased risk of QT interval prolongation Details Levofloxacin Risperidone Perseris Increased risk of QT interval prolongation Details Levofloxacin Ritonavir Norvir Increased risk of QT interval prolongation Details Levofloxacin Rosiglitazone Avandia® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Saxagliptin Onglyza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Selpercatinib Retevmo Increased risk of QT interval prolongation Details Levofloxacin Semaglutide Ozempic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.