Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Sertindole Increased risk of QT interval prolongation Details Levofloxacin Sevoflurane Petrem Increased risk of QT interval prolongation Details Levofloxacin Siponimod Mayzent An increased risk of QT interval prolongation Details Levofloxacin Sitagliptin Brynovin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Sodium Phosphate OsmoPrep Increased risk of QT interval prolongation Details Levofloxacin Sodium Phosphate, Dibasic Increased risk of QT interval prolongation Details Levofloxacin Sodium Phosphate, Monobasic Increased risk of QT interval prolongation Details Levofloxacin Solifenacin Vesicare Increased risk of QT interval prolongation Details Levofloxacin Sorafenib Nexavar Increased risk of QT interval prolongation Details Levofloxacin Sotalol Betapace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Sulpiride An increased risk of QT interval prolongation Details Levofloxacin Sunitinib Sutent Increased risk of QT interval prolongation Details Levofloxacin Tacrolimus Astagraf Increased risk of QT interval prolongation Details Levofloxacin Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Tamoxifen Nolvadex® Increased risk of QT interval prolongation Details Levofloxacin Telaprevir Increased risk of QT interval prolongation Details Levofloxacin Telavancin Vibativ Increased risk of QT interval prolongation Details Levofloxacin Telithromycin Increased risk of QT interval prolongation Details Levofloxacin Tetrabenazine Xenazine Increased risk of QT interval prolongation Details Levofloxacin Theophylline Accurbron® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Levofloxacin Tolazamide Tolinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Tolbutamide Orinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Tolterodine Detrol Increased risk of QT interval prolongation Details Levofloxacin Toremifene Fareston Increased risk of QT interval prolongation Details Levofloxacin Tramadol ConZip An increased risk of seizure Details Levofloxacin Trazodone Raldesy Increased risk of QT interval prolongation Details Levofloxacin Triamcinolone Aller-Cort An increased risk of tendon rupture Details Levofloxacin Triclabendazole Egaten An increased risk of QT interval prolongation Details Levofloxacin Trimipramine Increased risk of QT interval prolongation Details Levofloxacin Triptorelin Increased risk of QT interval prolongation Details Levofloxacin Vandetanib Caprelsa Increased risk of QT interval prolongation Details Levofloxacin Vardenafil Levitra Increased risk of QT interval prolongation Details Levofloxacin Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Levofloxacin Venlafaxine Increased risk of QT interval prolongation Details Levofloxacin Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Levofloxacin Vilanterol Increased risk of QT interval prolongation Details Levofloxacin Vinflunine Increased risk of QT-interval prolongation Details Levofloxacin Voclosporin Lupkynis An increased risk of QT interval prolongation Details Levofloxacin Voglibose Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Voriconazole Vfend Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.