Levofloxacin

406 interactions 547 cited references
Also sold as: Levaquin Levaquin®
About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin
12 Contraindicated 297 Major 97 Moderate
All (406) Contraindicated (12) Major (297) Moderate (97)

Major

Levofloxacin Vorinostat Zolinza Increased risk of QT interval prolongation Details Levofloxacin Warfarin Coumadin An increased risk of bleeding Details Levofloxacin Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Levofloxacin Zuclopenthixol An increased risk of QT interval prolongation Details Levofloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Levofloxacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Levofloxacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Levofloxacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Levofloxacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Levofloxacin Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Levofloxacin Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Levofloxacin Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Levofloxacin Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Levofloxacin Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Levofloxacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Levofloxacin Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.