Levonorgestrel Intrauterine System

211 interactions 370 cited references
Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®
About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir
6 Contraindicated 170 Major 34 Moderate 1 Minor
All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Major

Levonorgestrel Intrauterine System Lopinavir Altered (increased and reduced) levonorgestrel exposure Details Levonorgestrel Intrauterine System Lorlatinib Lorbrena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Lumacaftor Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Lymecycline Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Mavacamten Camzyos Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Levonorgestrel Intrauterine System Meclocycline Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Melatonin Increased melatonin exposure Details Levonorgestrel Intrauterine System Mephobarbital Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Levonorgestrel Intrauterine System Methacycline Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Methicillin Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Methohexital Brevital Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Methylergonovine Methergine Increased methylergonovine exposure Details Levonorgestrel Intrauterine System Methylprednisolone Depo-Medrol Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Mifepristone Korlym Reduced hormonal contraceptive exposure, an increased miFEPRIStone exposure and an increased hormonal contraceptives exposure Details Levonorgestrel Intrauterine System Minocycline Amzeeq Decreased contraceptive efficacy Details Levonorgestrel Intrauterine System Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Levonorgestrel Intrauterine System Mitotane Lysodren Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Mobocertinib Exkivity Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Modafinil Provigil Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Mycophenolate Mofetil Reduced levonorgestrel exposure and reduced efficacy of combination oral contraceptive Details Levonorgestrel Intrauterine System Mycophenolic Acid Myfortic Decreased contraceptive efficacy Details Levonorgestrel Intrauterine System Nafcillin Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Nelfinavir Viracept Increased nelfinavir exposure, reduced estrogen/progestin exposure and contraceptive failure Details Levonorgestrel Intrauterine System Nevirapine Viramune Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Nifedipine Adalat® Increased NIFEdipine exposure Details Levonorgestrel Intrauterine System Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Levonorgestrel Intrauterine System Omadacycline Nuzyra Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Omaveloxolone Skyclarys Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Orforglipron Foundayo Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Levonorgestrel Intrauterine System Oxacillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Oxcarbazepine Oxtellar Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Oxytetracycline Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Pacritinib Vonjo® Reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Penicillin G Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Penicillin G Procaine Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Penicillin V Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Pentobarbital Fatal-Plus Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Pexidartinib Turalio Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Phenobarbital Fidoquel Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details

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