Levonorgestrel Intrauterine System

Name: Levonorgestrel Intrauterine System Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

211 interactions 370 cited references

Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®

About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir

6 Contraindicated 170 Major 34 Moderate 1 Minor

All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Contraindicated

Levonorgestrel Intrauterine System Dasabuvir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Fezolinetant Increased fezolinetant exposure Details Levonorgestrel Intrauterine System Ombitasvir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Paritaprevir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Ritonavir Norvir An increased risk of ALT elevation, reduced progestin exposure and reduced efficacy of contraceptive Details Levonorgestrel Intrauterine System Tranexamic Acid Cyklokapron An increased risk of thrombotic events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.