Levonorgestrel Intrauterine System

211 interactions 370 cited references

Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®

About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir

6 Contraindicated 170 Major 34 Moderate 1 Minor

All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Contraindicated

Levonorgestrel Intrauterine System Dasabuvir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Fezolinetant Increased fezolinetant exposure Details Levonorgestrel Intrauterine System Ombitasvir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Paritaprevir An increased risk of ALT elevation Details Levonorgestrel Intrauterine System Ritonavir Norvir An increased risk of ALT elevation, reduced progestin exposure and reduced efficacy of contraceptive Details Levonorgestrel Intrauterine System Tranexamic Acid Cyklokapron An increased risk of thrombotic events Details

Major

Levonorgestrel Intrauterine System Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Levonorgestrel Intrauterine System Amobarbital Amytal Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Levonorgestrel Intrauterine System Ampicillin Amcill® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Amprenavir Reduced amprenavir exposure, altered hormonal levels, loss of contraceptive efficacy, and an increased risk of liver enzyme elevat... Details Levonorgestrel Intrauterine System Apalutamide Erleada Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Levonorgestrel Intrauterine System Armodafinil Nuvigil Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Bacampicillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Belzutifan Welireg Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Betamethasone Betavet Increased corticosteroid effects Details Levonorgestrel Intrauterine System Bexarotene Targretin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Bosentan Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Butabarbital Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Butalbital Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Carbamazepine Carbatrol Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Carbenicillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefaclor Ceclor® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefadroxil Duricef® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefdinir Omnicef® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefditoren Spectracef® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefixime Suprax Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefpodoxime Banan® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefprozil Cefzil® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Ceftazidime Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Ceftibuten Cedax® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cefuroxime Ceftin® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Cenobamate Xcopri Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Ceritinib Zykadia Increased CYP3A substrate exposure Details Levonorgestrel Intrauterine System Chlortetracycline Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Clobazam Onfi Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Clomipramine Anafranil Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Levonorgestrel Intrauterine System Cloxacillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Clozapine Clozaril Increased clozapine exposure and increased risk of adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.