Levonorgestrel Intrauterine System

211 interactions 370 cited references
Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®
About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir
6 Contraindicated 170 Major 34 Moderate 1 Minor
All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Major

Levonorgestrel Intrauterine System Topiramate Eprontia Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Tovorafenib Ojemda Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Levonorgestrel Intrauterine System Troleandomycin Increased contraceptive exposure and an increased risk of intrahepatic cholestasis Details Levonorgestrel Intrauterine System Ulipristal Ella Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Levonorgestrel Intrauterine System Vemurafenib Zelboraf Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Vorasidenib Voranigo Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposur... Details Levonorgestrel Intrauterine System Voriconazole Vfend Increased voriconazole exposure, increased ethinyl estradiol and norethindrone exposure Details Levonorgestrel Intrauterine System Warfarin Coumadin Altered warfarin exposure, reduced or increased anticoagulant effectiveness and altered INR Details Levonorgestrel Intrauterine System Zanubrutinib Brukinsa Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.