Licorice

38 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bisacodyl Bisacodyl Rectal Castor Oil Lactulose Linezolid Injection
5 Major 33 Moderate
All (38) Major (5) Moderate (33)

Major

Licorice Bisacodyl Alophen Reformulated Jan 2008 Increased risk of hypokalemia Details Licorice Bisacodyl Rectal Bisac-Evac Increased risk of hypokalemia Details Licorice Castor Oil Increased risk of hypokalemia Details Licorice Lactulose Cholac® Increased risk of hypokalemia Details Licorice Linezolid Injection Zyvox Increased risk of adverse effects from excessive inhibition of monoamine oxidase Details

Moderate

Licorice Acarbose Prandase® Explained Reduced antidiabetic agent effectiveness Details Licorice Acetazolamide Diamox® Sequels® Increased risk of hypokalemia and/or reduced effectiveness of the diuretic Details Licorice Aspirin Acuprin® Increased risk of bleeding Details Licorice Aspirin Rectal Aspirin Increased risk of bleeding Details Licorice Anagrelide Agrylin Increased risk of bleeding Details Licorice Becaplermin Topical Regranex Increased risk of bleeding Details Licorice Clopidogrel Plavix Increased risk of bleeding Details Licorice Dalteparin Injection Fragmin Increased risk of bleeding Details Licorice Defibrotide Injection Defitelio Increased risk of bleeding Details Licorice Dexamethasone Injection Decadron Increased risk of corticosteroid adverse effects Details Licorice Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of corticosteroid adverse effects Details Licorice Digoxin Cardoxin® Increased risk of digoxin toxicity Details Licorice Dipyridamole Permole® Increased risk of bleeding Details Licorice Enoxaparin Lovenox Increased risk of bleeding Details Licorice Enoxaparin Injection Lovenox Increased risk of bleeding Details Licorice Epoprostenol Flolan Increased risk of bleeding Details Licorice Estradiol Delestrogen Increased risk of fluid retention and elevated blood pressure Details Licorice Estradiol Topical Divigel Increased risk of fluid retention and elevated blood pressure Details Licorice Estradiol Transdermal Patch Alora® Increased risk of fluid retention and elevated blood pressure Details Licorice Fludrocortisone Acetate Florinef® Increased risk of corticosteroid adverse effects Details Licorice Fondaparinux Arixtra Increased risk of bleeding Details Licorice Fondaparinux Injection Arixtra Increased risk of bleeding Details Licorice Furosemide Injection Disal Increased risk of hypokalemia and/or reduced effectiveness of the diuretic Details Licorice Glimepiride Amaryl Reduced antidiabetic agent effectiveness Details Licorice Glipizide Glucotrol Reduced antidiabetic agent effectiveness Details Licorice Heparin Increased risk of bleeding Details Licorice Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Licorice Hydrocortisone Ala-Cort Increased risk of corticosteroid adverse effects Details Licorice Hydrocortisone Injection A-Hydrocort® Increased risk of corticosteroid adverse effects Details Licorice Iloprost Aurlumyn Increased risk of bleeding Details Licorice Levonorgestrel After banger Increased risk of fluid retention and elevated blood pressure Details Licorice Levonorgestrel Intrauterine System Kyleena Increased risk of fluid retention and elevated blood pressure Details Licorice Metformin Fortamet® Reduced antidiabetic agent effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.