Lithium Carbonate

317 interactions 813 cited references

Also sold as: Lithobid

Read the full Lithium Carbonate drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Phenelzine Tranylcypromine Zuclopenthixol Flufenamic Acid Floctafenine Feprazone

2 Contraindicated 279 Major 36 Moderate

All (317) Contraindicated (2) Major (279) Moderate (36)

Contraindicated

Lithium Carbonate Phenelzine Nardil An increased risk of serotonin syndrome and an increased risk of malignant hyperpyrexia Details Lithium Carbonate Tranylcypromine Parnate Increased risk of serotonin syndrome Details

Major

Lithium Carbonate Aceclofenac Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Acemetacin Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Acetazolamide Diamox® Sequels® Decreased lithium effectiveness or increased lithium concentrations Details Lithium Carbonate Acetophenazine Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Lithium Carbonate Alacepril Increased risk of lithium toxicity Details Lithium Carbonate Alclofenac Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Alfentanil Increased risk of serotonin syndrome Details Lithium Carbonate Almotriptan Increased risk of serotonin syndrome Details Lithium Carbonate Amifampridine Increased risk of seizures Details Lithium Carbonate Amineptine Increased risk of serotonin syndrome Details Lithium Carbonate Amitriptyline Elavil Increased risk of serotonin syndrome Details Lithium Carbonate Amitriptylinoxide Increased risk of serotonin syndrome Details Lithium Carbonate Amoxapine Increased risk of serotonin syndrome Details Lithium Carbonate Amphetamine Dexedrine An increased risk of serotonin syndrome Details Lithium Carbonate Amtolmetin Guacil Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Anileridine Increased risk of serotonin syndrome Details Lithium Carbonate Aspirin Acuprin® Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Azilsartan Medoxomil Edarbi Increased risk of lithium toxicity Details Lithium Carbonate Azosemide An increased risk of lithium toxicity Details Lithium Carbonate Bemetizide Lithium toxicity Details Lithium Carbonate Benazepril Lotensin Increased risk of lithium toxicity Details Lithium Carbonate Bendroflumethiazide Lithium toxicity Details Lithium Carbonate Benzhydrocodone Increased risk of serotonin syndrome Details Lithium Carbonate Benzphetamine An increased risk of serotonin syndrome Details Lithium Carbonate Benzthiazide Lithium toxicity Details Lithium Carbonate Bexagliflozin Reduced lithium exposure Details Lithium Carbonate Bromfenac Bromsite Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Bromperidol Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Lithium Carbonate Brompheniramine Respa-BR Increased risk of serotonin syndrome Details Lithium Carbonate Bufexamac Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Carbonate Bumetanide Bumex An increased risk of lithium toxicity Details Lithium Carbonate Buprenorphine Belbuca Increased risk of serotonin syndrome Details Lithium Carbonate Bupropion Aplenzin Increased risk of seizures Details Lithium Carbonate Buspirone Bucapsol Increased risk of serotonin syndrome Details Lithium Carbonate Butorphanol Butorphic Increased risk of serotonin syndrome Details Lithium Carbonate Canagliflozin Invokana Reduced lithium exposure Details Lithium Carbonate Candesartan Cilexetil Atacand Increased risk of lithium toxicity Details Lithium Carbonate Canrenoate Increased lithium concentrations and an increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion) Details

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