Lorlatinib and Medroxyprogesterone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lorlatinib
Medroxyprogesterone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced medroxyPROGESTERone exposure
Interaction Deep Dive
There have been reports of breakthrough bleeding and pregnancies during coadministration of carBAMazepine with hormonal contraceptives2. Avoid coadministration of medroxyPROGESTERone acetate with moderate or strong CYP3A inducers. If used for contraception, concomitant use of medroxyPROGESTERone acetate with CYP3A inducers may require a back-up or alternate contraceptive method 1.
Why it happens (mechanism)
Induction of CYP3A-mediated metabolism of medroxyPROGESTERone
Literature reports
1 report — tap to read
a) If medroxyPROGESTERone is being used as a hormonal contraceptive, there have been reports of breakthrough bleeding and pregnancies during coadministration of carBAMazepine with hormonal contraceptives 2.
Common questions
Can I take Lorlatinib and Medroxyprogesterone together?
Reduced medroxyPROGESTERone exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lorlatinib and Medroxyprogesterone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Lorlatinib or Medroxyprogesterone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: depo-subQ provera 104(R) subcutaneous injection, medroxyprogesterone acetate subcutaneous injection. Pharmacia and Upjohn Co (per manufacturer), New York, NY, 2019. DailyMed
- Product Information: Tegretol(R)-XR oral extended release tablets, carbamazepine oral extended release tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2014. DailyMed
Keep reading about Lorlatinib
Keep reading about Medroxyprogesterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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