Loxoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Ketorolac Nasal Spray Ketorolac Injection Diclofenac Ophthalmic Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Loxoprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Loxoprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Loxoprofen Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Loxoprofen Iloprost Aurlumyn An increased risk of bleeding Details Loxoprofen Ketoprofen Actron® Increased risk of bleeding Details Loxoprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Loxoprofen Meclofenamate Meclodium® Increased risk of bleeding Details Loxoprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Loxoprofen Meloxicam Alloxate Increased risk of bleeding Details Loxoprofen Meloxicam Injection Alloxate Increased risk of bleeding Details Loxoprofen Melphalan Alkeran An increased risk of bleeding Details Loxoprofen Melphalan Injection Alkeran An increased risk of bleeding Details Loxoprofen Mesalamine Apriso Increased risk of bleeding Details Loxoprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Loxoprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Loxoprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Loxoprofen Nabumetone Relafen Increased risk of bleeding Details Loxoprofen Naproxen Aleve Increased risk of bleeding Details Loxoprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.