Loxoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Ketorolac Nasal Spray Ketorolac Injection Diclofenac Ophthalmic Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Moderate

Loxoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Loxoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Loxoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Loxoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Loxoprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Loxoprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Loxoprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Esmolol Brevibloc Reduced antihypertensive effect Details Loxoprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Labetalol Normodyne® Reduced antihypertensive effect Details Loxoprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Loxoprofen Levofloxacin Levaquin An increased risk of seizures Details Loxoprofen Levofloxacin Injection Levaquin An increased risk of seizures Details Loxoprofen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Nadolol Corgard Reduced antihypertensive effect Details Loxoprofen Nebivolol Bystolic Reduced antihypertensive effect Details Loxoprofen Ofloxacin Floxin® An increased risk of seizures Details Loxoprofen Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Loxoprofen Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Loxoprofen Penbutolol Levatol® Reduced antihypertensive effect Details Loxoprofen Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.