Magaldrate and Mefenamic Acid: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mefenamic Acid
Magaldrate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to mefenamic acid
Interaction Deep Dive
Coadministration of mefenamic acid and an antacid may increase plasma concentrations and exposure to mefenamic acid. Mefenamic acid 500 mg given with magnesium hydroxide 1.7 g resulted in an increase in mefenamic acid Cmax by 125% and the AUC by 36% (N=6). Concomitant use of mefenamic acid with an antacid is generally not recommended1. If concurrent use cannot be avoided, monitor for possible NSAID toxicity and adjust the doses accordingly.
Why it happens (mechanism)
Increased absorption of mefenamic acid
Common questions
Can I take Magaldrate and Mefenamic Acid together?
Increased exposure to mefenamic acid Always confirm with your pharmacist or prescriber before making any change.
How serious is the Magaldrate and Mefenamic Acid interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Magaldrate or Mefenamic Acid need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: mefenamic acid oral capsules, mefenamic acid oral capsules. Prasco Laboratories (per FDA), Mason, OH, 2016. DailyMed
Keep reading about Mefenamic Acid
Keep reading about Magaldrate
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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