Magnesium Hydroxide

53 interactions 1 explained in plain English
Also sold as: Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Alumox® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) ConRX® AR (containing Aluminum Hydroxide, Magnesium Hydroxide) Duo Fusion® (containing Calcium Carbonate, Famotidine, Magnesium Hydroxide) Milk of Magnesia® Mirafast Pedia-Lax Chewable Pedia-Lax® Phillips Milk of Magnesia
About Magnesium Hydroxide

Magnesium hydroxide is a saline laxative used to treat occasional constipation by softening stool and increasing bowel movements. Read the full Magnesium Hydroxide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefenamic Acid Neratinib Octreotide Injection Hydroxychloroquine Erdafitinib Infigratinib
14 Major 30 Moderate 9 Minor
All (53) Major (14) Moderate (30) Minor (9)

Major

Magnesium Hydroxide Acalabrutinib Calquence Reduced acalabrutinib exposure Details Magnesium Hydroxide Cabotegravir Apretude Reduced cabotegravir plasma concentrations Details Magnesium Hydroxide Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Magnesium Hydroxide Digoxin Cardoxin® Reduced digoxin exposure Details Magnesium Hydroxide Erdafitinib Balversa Altered serum phosphate levels Details Magnesium Hydroxide Ezetimibe Zetia Reduced ezetimibe exposure Details Magnesium Hydroxide Gefitinib Iressa Decreased exposure of gefitinib Details Magnesium Hydroxide Hydroxychloroquine Plaquenil Reduced hydroxychloroquine exposure Details Magnesium Hydroxide Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Magnesium Hydroxide Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Magnesium Hydroxide Mefenamic Acid Ponstel® Increased exposure to mefenamic acid Details Magnesium Hydroxide Neratinib Nerlynx Decreased neratinib exposure Details Magnesium Hydroxide Octreotide Bynfezia Decreased octreotide bioavailability Details Magnesium Hydroxide Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Magnesium Hydroxide Aspirin Acuprin® Decreased salicylate effectiveness Details Magnesium Hydroxide Aspirin Rectal Aspirin Decreased salicylate effectiveness Details Magnesium Hydroxide Bosutinib Bosulif Reduced bosutinib exposure Details Magnesium Hydroxide Calcitriol Rocaltrol Hypermagnesemia Details Magnesium Hydroxide Calcitriol Topical Vectical Hypermagnesemia Details Magnesium Hydroxide Captopril Capoten® Decreased captopril effectiveness Details Magnesium Hydroxide Cefdinir Omnicef® Decreased cefdinir efficacy Details Magnesium Hydroxide Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Magnesium Hydroxide Chloroquine Aralen® Decreased efficacy of chloroquine Details Magnesium Hydroxide Dasatinib Phyrago Reduced dasatinib exposure Details Magnesium Hydroxide Deflazacort Emflaza Decreased deflazacort effectiveness Details Magnesium Hydroxide Erlotinib Tarceva Reduced erlotinib exposure Details Magnesium Hydroxide Fexofenadine Allegra Decreased fexofenadine efficacy Details Magnesium Hydroxide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Magnesium Hydroxide Gemifloxacin Factive Decreased oral gemifloxacin effectiveness Details Magnesium Hydroxide Ibandronate Boniva Decreased ibandronate effectiveness Details Magnesium Hydroxide Ibandronate Injection Boniva Decreased ibandronate effectiveness Details Magnesium Hydroxide Levofloxacin Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Hydroxide Levofloxacin Injection Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Hydroxide Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Magnesium Hydroxide Mesalamine Apriso Alteration of mesalamine bioavailability Details Magnesium Hydroxide Mesalamine Rectal Canasa Alteration of mesalamine bioavailability Details Magnesium Hydroxide Moxifloxacin Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Hydroxide Moxifloxacin Injection Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Hydroxide Moxifloxacin Ophthalmic Moxeza® Decreased oral moxifloxacin effectiveness Details Magnesium Hydroxide Ofloxacin Floxin® Decreased oral ofloxacin effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.