Magnesium Trisilicate

52 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefenamic Acid Neratinib Octreotide Injection Hydroxychloroquine Erdafitinib Infigratinib

14 Major 30 Moderate 8 Minor

All (52) Major (14) Moderate (30) Minor (8)

Moderate

Magnesium Trisilicate Aspirin Acuprin® Decreased salicylate effectiveness Details Magnesium Trisilicate Aspirin Rectal Aspirin Decreased salicylate effectiveness Details Magnesium Trisilicate Bosutinib Bosulif Reduced bosutinib exposure Details Magnesium Trisilicate Calcitriol Rocaltrol Hypermagnesemia Details Magnesium Trisilicate Calcitriol Topical Vectical Hypermagnesemia Details Magnesium Trisilicate Captopril Capoten® Decreased captopril effectiveness Details Magnesium Trisilicate Cefdinir Omnicef® Decreased cefdinir efficacy Details Magnesium Trisilicate Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Magnesium Trisilicate Chloroquine Aralen® Decreased efficacy of chloroquine Details Magnesium Trisilicate Dasatinib Phyrago Reduced dasatinib exposure Details Magnesium Trisilicate Deflazacort Emflaza Decreased deflazacort effectiveness Details Magnesium Trisilicate Erlotinib Tarceva Reduced erlotinib exposure Details Magnesium Trisilicate Fexofenadine Allegra Decreased fexofenadine efficacy Details Magnesium Trisilicate Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Magnesium Trisilicate Gemifloxacin Factive Decreased oral gemifloxacin effectiveness Details Magnesium Trisilicate Ibandronate Boniva Decreased ibandronate effectiveness Details Magnesium Trisilicate Ibandronate Injection Boniva Decreased ibandronate effectiveness Details Magnesium Trisilicate Levofloxacin Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Trisilicate Levofloxacin Injection Levaquin Decreased oral levofloxacin effectiveness Details Magnesium Trisilicate Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Magnesium Trisilicate Mesalamine Apriso Alteration of mesalamine bioavailability Details Magnesium Trisilicate Mesalamine Rectal Canasa Alteration of mesalamine bioavailability Details Magnesium Trisilicate Moxifloxacin Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Trisilicate Moxifloxacin Injection Avelox Decreased oral moxifloxacin effectiveness Details Magnesium Trisilicate Moxifloxacin Ophthalmic Moxeza® Decreased oral moxifloxacin effectiveness Details Magnesium Trisilicate Ofloxacin Floxin® Decreased oral ofloxacin effectiveness Details Magnesium Trisilicate Ofloxacin Ophthalmic Ocuflox Decreased oral ofloxacin effectiveness Details Magnesium Trisilicate Ofloxacin Otic Floxin® Otic Decreased oral ofloxacin effectiveness Details Magnesium Trisilicate Omadacycline Nuzyra Decreased effectiveness of omadacycline Details Magnesium Trisilicate Omadacycline Injection Nuzyra Decreased effectiveness of omadacycline Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.