Magnesium and Delafloxacin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Delafloxacin
Magnesium
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased delafloxacin efficacy
Interaction Deep Dive
Concurrent administration of ciprofloxacin with products containing chelating agents (eg, antacids, sucralfate, metal cations, and multivitamins) should be avoided. Take delafloxacin at least two hours before or six hours after taking these products1.
Why it happens (mechanism)
Decreased gastrointestinal absorption
Common questions
Can I take Magnesium and Delafloxacin together?
Decreased delafloxacin efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Magnesium and Delafloxacin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Magnesium or Delafloxacin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: BAXDELA(TM) oral tablets, intravenous injection, delafloxacin oral tablets, intravenous injection. Melinta Therapeutics, Inc (per FDA), Lincolnshire, IL, 2017. DailyMed
Keep reading about Delafloxacin
Keep reading about Magnesium
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