Manidipine

Name: Manidipine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clonidine Transdermal Patch Digoxin Epirubicin Ketoconazole Topical Lacosamide Injection Melphalan

7 Major 1 Moderate

All (8) Major (7) Moderate (1)

Major

Manidipine Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Manidipine Digoxin Cardoxin® An increased risk of bradycardia and an increased risk of complete heart block Details Manidipine Epirubicin Ellence Increased risk of heart failure Details Manidipine Ketoconazole Topical Extina® Foam Increased manidipine exposure Details Manidipine Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Manidipine Melphalan Alkeran An increased risk of severe hypotension Details Manidipine Melphalan Injection Alkeran An increased risk of severe hypotension Details

Moderate

Manidipine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.