Maribavir and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Maribavir
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased cycloSPORINE exposure and an increased cycloSPORINE-related adverse events
Interaction Deep Dive
Coadministration of maribavir with cycloSPORINE (P-gp substrate with NTI) may result in increased exposure of cycloSPORINE, that may lead to serious adverse events. Frequently monitor cycloSPORINE levels throughout treatment with maribavir, especially following initiation and after discontinuation of maribavir and adjust dose, as needed1.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport of maribavir; inhibition of immunosuppressant metabolism of cycloSPORINE
Common questions
Can I take Maribavir and Cyclosporine Injection together?
Increased cycloSPORINE exposure and an increased cycloSPORINE-related adverse events Always confirm with your pharmacist or prescriber before making any change.
How serious is the Maribavir and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Maribavir or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIVTENCITY® oral tablets, maribavir oral tablets. Takeda Pharmaceuticals America Inc (per FDA), Cambridge, MA, 2025. DailyMed
Keep reading about Maribavir
Keep reading about Cyclosporine Injection
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