Meclizine

29 interactions 2 explained in plain English

Also sold as: Antivert Bonine Dramamine Less Drowsy Dramamine Nausea Relief Pepto Nausea Verticalm Wal-Dram 2 Zentrip

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Nalbuphine Injection Levodopa Oral Inhalation Glycopyrronium Topical Cetirizine Injection Esketamine Nasal Spray

27 Major 2 Moderate

All (29) Major (27) Moderate (2)

Major

Meclizine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Meclizine Buprenorphine Belbuca Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Meclizine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Meclizine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Meclizine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Meclizine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Meclizine Diazepam Nasal Spray Valtoco An increase in CNS or respiratory depression Details Meclizine Diazepam Rectal Diastat An increase in CNS or respiratory depression Details Meclizine Diphenhydramine Injection Banophen An increase in CNS or respiratory depression Details Meclizine Diphenhydramine Topical Afterbite with Antihistamine An increase in CNS or respiratory depression Details Meclizine Esketamine Nasal Spray Spravato Increased risk of sedation Details Meclizine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Meclizine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Meclizine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Meclizine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Meclizine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Meclizine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Meclizine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Meclizine Hydroxychloroquine Plaquenil An increased risk of seizures Details Meclizine Lacosamide Injection Motpoly An increased risk of CNS depression Details Meclizine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Meclizine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Meclizine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Meclizine Midazolam Nasal Spray Nayzilam An increase in CNS or respiratory depression Details Meclizine Midazolam Injection Nayzilam An increase in CNS or respiratory depression Details Meclizine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Meclizine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details

Moderate

Meclizine Abiraterone Abirtega Increased meclizine exposure Details Meclizine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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