Drug Interaction Report

Meclizine and Abiraterone: Interaction Details

A pharmacist-reviewed analysis of the Meclizine and Abiraterone interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Meclizine

Antivert Bonine Dramamine Less Drowsy Dramamine Nausea Relief Pepto Nausea Verticalm Wal-Dram 2 Zentrip
+

Abiraterone

Abirtega Yonsa Zytiga Zytiga®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 29 documented Meclizine interactions, 2 are rated moderate — including this one.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

Increased meclizine exposure

Interaction Deep Dive

CYP2D6 is the primary pathway for meclizine metabolism in vitro123. Coadministration of meclizine with certain CYP2D6 inhibitors may result in increased meclizine exposure and risk of adverse effects. If concomitant use is necessary, use caution and consider monitoring patients for increased meclizine adverse effects.

Why it happens (mechanism)

Inhibition of CYP2D6-mediated meclizine metabolism

Common questions

Can I take Meclizine and Abiraterone together?

Increased meclizine exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Meclizine and Abiraterone interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Meclizine or Abiraterone need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: ANTIVERT(R) oral tablets, meclizine HCl oral tablets. Pfizer Inc. (per FDA), New York, NY, 2012. DailyMed
  2. Product Information: ANTIVERT(R)/25 oral tablets, meclizine HCl 25mg oral tablets. Pfizer Inc. (per FDA), New York, NY, 2012. DailyMed
  3. Product Information: ANTIVERT(R)/50 oral tablets, meclizine HCl 50mg oral tablets. Pfizer Inc. (per FDA), New York, NY, 2012.
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Meclizine

Keep reading about Meclizine

All Meclizine interactions (29)
Also serious with: Acetaminophen And Codeine Levodopa Oral Inhalation Nalbuphine Injection Glycopyrronium Topical
Abiraterone

Keep reading about Abiraterone

All Abiraterone interactions (164) Abiraterone drug information
Also serious with: Ensitrelvir Abametapir Acarbose Albiglutide
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Meclizine + Activated Charcoal Henbane Scopolia Angel's Trumpet Bacopa Belladonna Betel Nut Boxwood + 38 more
Abiraterone + Activated Charcoal Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Adrafinil + 173 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.