Meclofenamate

290 interactions 246 cited references
Also sold as: Meclodium® Meclomen®
About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide
4 Contraindicated 226 Major 60 Moderate
All (290) Contraindicated (4) Major (226) Moderate (60)

Moderate

Meclofenamate Norfloxacin An increased risk of seizures Details Meclofenamate Ofloxacin Floxin® An increased risk of seizures Details Meclofenamate Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Oxprenolol Reduced antihypertensive effect Details Meclofenamate Penbutolol Levatol® Reduced antihypertensive effect Details Meclofenamate Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Pindolol Visken® Reduced antihypertensive effect Details Meclofenamate Pralatrexate Increased pralatrexate exposure Details Meclofenamate Propranolol Hemangeol Reduced antihypertensive effect Details Meclofenamate Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Sotalol Betapace Reduced antihypertensive effect Details Meclofenamate Sparsentan Filspari An increased risk of worsening of renal function Details Meclofenamate Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Timolol Betimol Reduced antihypertensive effect Details Meclofenamate Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Meclofenamate Ofloxacin Otic Floxin® Otic An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.