Meclofenamate

290 interactions 246 cited references
Also sold as: Meclodium® Meclomen®
About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide
4 Contraindicated 226 Major 60 Moderate
All (290) Contraindicated (4) Major (226) Moderate (60)

Contraindicated

Meclofenamate Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Meclofenamate Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Meclofenamate Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Meclofenamate Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Meclofenamate Amitriptyline Elavil An increased risk of bleeding Details Meclofenamate Sertraline An increased risk of bleeding Details Meclofenamate Apixaban Eliquis An increased risk of bleeding Details Meclofenamate Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Meclofenamate Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Meclofenamate Betrixaban Bevyxxa® An increased risk of bleeding Details Meclofenamate Anagrelide Agrylin An increased risk of bleeding Details Meclofenamate Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Meclofenamate Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Clopidogrel Plavix An increased risk of bleeding Details Meclofenamate Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Meclofenamate Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Meclofenamate Dabigatran Pradaxa® An increased risk of bleeding Details Meclofenamate Dabigatran Etexilate An increased risk of bleeding Details Meclofenamate Dalteparin Injection Fragmin An increased risk of bleeding Details Meclofenamate Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Meclofenamate Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Meclofenamate Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Meclofenamate Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Meclofenamate Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Meclofenamate Dipyridamole Permole® An increased risk of bleeding Details Meclofenamate Edoxaban Savaysa An increased risk of bleeding Details Meclofenamate Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Meclofenamate Enoxaparin Lovenox An increased risk of bleeding Details Meclofenamate Enoxaparin Injection Lovenox An increased risk of bleeding Details Meclofenamate Epoprostenol Flolan An increased risk of bleeding Details Meclofenamate Etodolac Lodine Increased risk of bleeding Details Meclofenamate Fenoprofen Fenopron Increased risk of bleeding Details Meclofenamate Flurbiprofen Ansaid Increased risk of bleeding Details Meclofenamate Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Meclofenamate Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.