Meclofenamate

290 interactions 246 cited references

Also sold as: Meclodium® Meclomen®

About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide

4 Contraindicated 226 Major 60 Moderate

All (290) Contraindicated (4) Major (226) Moderate (60)

Major

Meclofenamate Fondaparinux Injection Arixtra An increased risk of bleeding Details Meclofenamate Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Heparin An increased risk of bleeding Details Meclofenamate Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Meclofenamate Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Meclofenamate Iloprost Aurlumyn An increased risk of bleeding Details Meclofenamate Ketoprofen Actron® Increased risk of bleeding Details Meclofenamate Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Meclofenamate Abciximab An increased risk of bleeding Details Meclofenamate Aceclofenac Increased risk of bleeding Details Meclofenamate Acemetacin Increased risk of bleeding Details Meclofenamate Acenocoumarol An increased risk of bleeding Details Meclofenamate Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Meclofenamate Amineptine An increased risk of bleeding Details Meclofenamate Amitriptylinoxide An increased risk of bleeding Details Meclofenamate Amoxapine An increased risk of bleeding Details Meclofenamate Amtolmetin Guacil Increased risk of bleeding Details Meclofenamate Ardeparin An increased risk of bleeding Details Meclofenamate Argatroban An increased risk of bleeding Details Meclofenamate Balsalazide Colazal Increased risk of bleeding Details Meclofenamate Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Bemiparin An increased risk of bleeding Details Meclofenamate Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Meclofenamate Bivalirudin Angiomax An increased risk of bleeding Details Meclofenamate Bromfenac Bromsite Increased risk of bleeding Details Meclofenamate Bufexamac Increased risk of bleeding Details Meclofenamate Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Cangrelor Kengreal An increased risk of bleeding Details Meclofenamate Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Meclofenamate Certoparin An increased risk of bleeding Details Meclofenamate Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Meclofenamate Choline Salicylate Increased risk of bleeding Details Meclofenamate Cilostazol Pletal® An increased risk of bleeding Details Meclofenamate Citalopram Celexa An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.