Meclofenamate

290 interactions 246 cited references

Also sold as: Meclodium® Meclomen®

About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide

4 Contraindicated 226 Major 60 Moderate

All (290) Contraindicated (4) Major (226) Moderate (60)

Major

Meclofenamate Clomipramine Anafranil An increased risk of bleeding Details Meclofenamate Clonixin Increased risk of bleeding Details Meclofenamate Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Meclofenamate Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Dalteparin Fragmin An increased risk of bleeding Details Meclofenamate Danaparoid An increased risk of bleeding Details Meclofenamate Desipramine Norpramin An increased risk of bleeding Details Meclofenamate Desirudin Iprivask An increased risk of bleeding Details Meclofenamate Desvenlafaxine Pristiq An increased risk of bleeding Details Meclofenamate Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Dexibuprofen Increased risk of bleeding Details Meclofenamate Dexketoprofen Increased risk of bleeding Details Meclofenamate Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Dibenzepin An increased risk of bleeding Details Meclofenamate Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Meclofenamate Diflunisal Dolobid Increased risk of bleeding Details Meclofenamate Dipyrone Increased risk of bleeding Details Meclofenamate Dothiepin An increased risk of bleeding Details Meclofenamate Doxepin Prudoxin An increased risk of bleeding Details Meclofenamate Droxicam Increased risk of bleeding Details Meclofenamate Duloxetine An increased risk of bleeding Details Meclofenamate Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Meclofenamate Eptifibatide An increased risk of bleeding Details Meclofenamate Escitalopram Lexapro An increased risk of bleeding Details Meclofenamate Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Etofenamate Increased risk of bleeding Details Meclofenamate Etoricoxib Increased risk of bleeding Details Meclofenamate Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Felbinac Increased risk of bleeding Details Meclofenamate Fepradinol Increased risk of bleeding Details Meclofenamate Feprazone Increased risk of bleeding Details Meclofenamate Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Meclofenamate Floctafenine Increased risk of bleeding Details Meclofenamate Flufenamic Acid Increased risk of bleeding Details Meclofenamate Fluoxetine RECONCILE An increased risk of bleeding Details Meclofenamate Fluvoxamine An increased risk of bleeding Details Meclofenamate Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Gossypol Increased risk of adverse gastrointestinal effects Details

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