Meclofenamate

290 interactions 246 cited references
Also sold as: Meclodium® Meclomen®
About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Meclofenamate Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Imipramine An increased risk of bleeding Details Meclofenamate Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Indomethacin Indocin Increased risk of bleeding Details Meclofenamate Inotersen Increased risk of bleeding Details Meclofenamate Lepirudin An increased risk of bleeding Details Meclofenamate Levomilnacipran An increased risk of bleeding Details Meclofenamate Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Meclofenamate Lofepramine An increased risk of bleeding Details Meclofenamate Lornoxicam Increased risk of bleeding Details Meclofenamate Loxoprofen Increased risk of bleeding Details Meclofenamate Lumiracoxib Increased risk of bleeding Details Meclofenamate Magnesium Salicylate Increased risk of bleeding Details Meclofenamate Meadowsweet Increased risk of bleeding Details Meclofenamate Mefenamic Acid Ponstel® Increased risk of bleeding Details Meclofenamate Melitracen An increased risk of bleeding Details Meclofenamate Meloxicam Alloxate Increased risk of bleeding Details Meclofenamate Melphalan Alkeran An increased risk of bleeding Details Meclofenamate Mesalamine Apriso Increased risk of bleeding Details Meclofenamate Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Meclofenamate Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Milnacipran Savella An increased risk of bleeding Details Meclofenamate Morniflumate Increased risk of bleeding Details Meclofenamate Nabumetone Relafen Increased risk of bleeding Details Meclofenamate Nadroparin An increased risk of bleeding Details Meclofenamate Naproxen Aleve Increased risk of bleeding Details Meclofenamate Nefazodone An increased risk of bleeding Details Meclofenamate Nepafenac Ilevro Increased risk of bleeding Details Meclofenamate Niflumic Acid Increased risk of bleeding Details Meclofenamate Nimesulide Increased risk of bleeding Details Meclofenamate Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Meclofenamate Nortriptyline An increased risk of bleeding Details Meclofenamate Olsalazine Dipentum Increased risk of bleeding Details Meclofenamate Opipramol An increased risk of bleeding Details Meclofenamate Oxaprozin Coxanto Increased risk of bleeding Details Meclofenamate Oxyphenbutazone Increased risk of bleeding Details Meclofenamate Parecoxib Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.