Meclofenamate

290 interactions 246 cited references

Also sold as: Meclodium® Meclomen®

About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide

4 Contraindicated 226 Major 60 Moderate

All (290) Contraindicated (4) Major (226) Moderate (60)

Major

Meclofenamate Parnaparin An increased risk of bleeding Details Meclofenamate Paroxetine Paxil An increased risk of bleeding Details Meclofenamate Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Meclofenamate Pentosan Polysulfate Sodium An increased risk of bleeding Details Meclofenamate Pentoxifylline Pentoxil® An increased risk of bleeding Details Meclofenamate Phenindione An increased risk of bleeding Details Meclofenamate Phenprocoumon An increased risk of bleeding Details Meclofenamate Phenylbutazone Equi-Phar Increased risk of bleeding Details Meclofenamate Phenyl Salicylate Increased risk of bleeding Details Meclofenamate Piketoprofen Increased risk of bleeding Details Meclofenamate Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Piroxicam Feldene Increased risk of bleeding Details Meclofenamate Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Meclofenamate Prasugrel Effient An increased risk of bleeding Details Meclofenamate Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Meclofenamate Probenecid Increased risk of meclofenamate exposure and an increased risk of meclofenamate-related adverse reactions Details Meclofenamate Proglumetacin Increased risk of bleeding Details Meclofenamate Propyphenazone Increased risk of bleeding Details Meclofenamate Proquazone Increased risk of bleeding Details Meclofenamate Protein C Ceprotin An increased risk of bleeding Details Meclofenamate Protriptyline An increased risk of bleeding Details Meclofenamate Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Reviparin An increased risk of bleeding Details Meclofenamate Rivaroxaban Xarelto An increased risk of bleeding Details Meclofenamate Rofecoxib Increased risk of bleeding Details Meclofenamate Salicylamide Increased risk of bleeding Details Meclofenamate Salicylic Acid Increased risk of bleeding Details Meclofenamate Salsalate Disalcid Increased risk of bleeding Details Meclofenamate Selexipag Uptravi An increased risk of bleeding Details Meclofenamate Sibutramine An increased risk of bleeding Details Meclofenamate Sodium Salicylate Increased risk of bleeding Details Meclofenamate Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Meclofenamate Sulfasalazine Azulfidine Increased risk of bleeding Details Meclofenamate Sulfinpyrazone An increased risk of bleeding Details Meclofenamate Sulindac Clinoril® Increased risk of bleeding Details Meclofenamate Sulodexide An increased risk of bleeding Details Meclofenamate Tacrolimus Astagraf Acute renal failure Details Meclofenamate Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details

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