Meclofenamate

290 interactions 246 cited references

Also sold as: Meclodium® Meclomen®

About Meclofenamate

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, includin… Read the full Meclofenamate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Cyclopenthiazide Clopamide

4 Contraindicated 226 Major 60 Moderate

All (290) Contraindicated (4) Major (226) Moderate (60)

Major

Meclofenamate Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Meclofenamate Tenoxicam Increased risk of bleeding Details Meclofenamate Tianeptine An increased risk of bleeding Details Meclofenamate Tiaprofenic Acid Increased risk of bleeding Details Meclofenamate Ticagrelor Brilinta An increased risk of bleeding Details Meclofenamate Ticlopidine Ticlid® An increased risk of bleeding Details Meclofenamate Tinzaparin An increased risk of bleeding Details Meclofenamate Tirofiban An increased risk of bleeding Details Meclofenamate Tolfenamic Acid Increased risk of bleeding Details Meclofenamate Tolmetin Tolectin 600 Increased risk of bleeding Details Meclofenamate Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Trazodone Raldesy An increased risk of bleeding Details Meclofenamate Treprostinil Orenitram An increased risk of bleeding Details Meclofenamate Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Meclofenamate Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Trimipramine An increased risk of bleeding Details Meclofenamate Trolamine Salicylate Increased risk of bleeding Details Meclofenamate Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Meclofenamate Valdecoxib Increased risk of bleeding Details Meclofenamate Venlafaxine An increased risk of bleeding Details Meclofenamate Vilazodone Viibryd An increased risk of bleeding Details Meclofenamate Vorapaxar Zontivity An increased risk of bleeding Details Meclofenamate Vortioxetine Trintellix An increased risk of bleeding Details Meclofenamate Warfarin Coumadin An increased risk of bleeding Details Meclofenamate Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details Meclofenamate Meloxicam Injection Alloxate Increased risk of bleeding Details Meclofenamate Melphalan Injection Alkeran An increased risk of bleeding Details Meclofenamate Mesalamine Rectal Canasa Increased risk of bleeding Details Meclofenamate Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Meclofenamate Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Meclofenamate Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Atenolol Tenormin Reduced antihypertensive effect Details Meclofenamate Acebutolol Sectral® Reduced antihypertensive effect Details Meclofenamate Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Betaxolol Betoptic S Reduced antihypertensive effect Details Meclofenamate Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Meclofenamate Bisoprolol Zebeta® Reduced antihypertensive effect Details Meclofenamate Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Meclofenamate Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.