Medroxyprogesterone and Vorasidenib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Medroxyprogesterone
Vorasidenib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposure, an increased risk of contraception failure and/or an increase in breakthrough bleeding
Interaction Deep Dive
In a drug interaction study, concomitant use of ciprofloxacin (moderate CYP1A2 inhibitor) increased vorasidenib plasma Cmax 1.3-fold and AUC 2.5-fold. Avoid concomitant use of vorasidenib with a hormonal contraceptives as it may reduce the exposure of hormonal contraceptives, which may lead to contraception failure and/or an increase in breakthrough bleeding. Also, concomitant use of vorasidenib with a hormonal contraceptive (moderate CYP1A2 inhibitor) may increase vorasidenib exposure. If concomitant use cannot be avoided, monitor for increased adverse reactions, modify the dosage for adverse reactions as necessary and use nonhormonal contraception methods. Advise females of reproductive potential to use effective nonhormonal contraception during treatment with vorasidenib and for 3 months after the last dose1.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated metabolism of vorasidenib
Literature reports
1 report — tap to read
a) In a drug interaction study, concomitant use of ciprofloxacin (moderate CYP1A2 inhibitor) increased vorasidenib plasma Cmax 1.3-fold and AUC 2.5-fold 1.
Common questions
Can I take Medroxyprogesterone and Vorasidenib together?
Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposure, an increased risk of contraception failure and/or an increase in breakthrough bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Medroxyprogesterone and Vorasidenib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Medroxyprogesterone or Vorasidenib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VORANIGO® oral tablets, vorasidenib oral tablets. Servier Pharmaceuticals LLC (per FDA), Boston, MA, 2024. DailyMed
Keep reading about Medroxyprogesterone
Keep reading about Vorasidenib
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