Medroxyprogesterone

108 interactions 317 cited references
Also sold as: Amen® Curretab® Cycrin® Depo-Provera depo-subQ provera Prodroxy® Provera Provera®
About Medroxyprogesterone

A progestin hormone medication used to treat abnormal bleeding and regulate menstrual periods in women. Read the full Medroxyprogesterone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Tranexamic Acid Typhoid Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live
11 Contraindicated 91 Major 6 Moderate
All (108) Contraindicated (11) Major (91) Moderate (6)

Major

Medroxyprogesterone Suzetrigine Journavx Reduced progestin-only contraceptives exposure and reduced efficacy of progestin-only contraceptives Details Medroxyprogesterone Tazemetostat Tazverik Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Telaprevir Decreased contraceptive effectiveness Details Medroxyprogesterone Theophylline Accurbron® Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Medroxyprogesterone Topiramate Eprontia Reduced hormonal contraceptive exposure, reduced contraceptive efficacy and an increased risk of breakthrough bleeding/contracepti... Details Medroxyprogesterone Tovorafenib Ojemda Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Medroxyprogesterone Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Medroxyprogesterone Ulipristal Ella Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Medroxyprogesterone Vorasidenib Voranigo Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposur... Details Medroxyprogesterone Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Medroxyprogesterone Nafcillin Injection Unipen® Injection Reduced medroxyPROGESTERone exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.