Megestrol

Name: Megestrol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

2 interactions 162 cited references

Also sold as: Megace® Megace® ES

About Megestrol

Megestrol tablets are used to relieve the symptoms and reduce the suffering caused by advanced breast cancer and advanced endometrial cancer (cancer that begins in the lining of the uterus). Megestrol suspension is used to treat loss of appetite, malnutrition, and severe weight loss in patients with acquired immunodefi… Read the full Megestrol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Warfarin

1 Contraindicated 1 Major

All (2) Contraindicated (1) Major (1)

Contraindicated

Megestrol Dofetilide Tikosyn Increased dofetilide exposure and an increased risk of QT interval prolongation, and an increased risk of torsades de pointes Details

Major

Megestrol Warfarin Coumadin An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.