Melatonin

23 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Labetalol Estradiol Topical Penbutolol Atenolol Medroxyprogesterone Ibuprofen
22 Major 1 Minor
All (23) Major (22) Minor (1)

Major

Melatonin Abametapir Explained Increased exposure of CYP1A2 substrates Details Melatonin Aspirin Acuprin® An increased risk of suppression of endogenous melatonin levels Details Melatonin Aspirin Rectal Aspirin An increased risk of suppression of endogenous melatonin levels Details Melatonin Atenolol Tenormin Explained An increased risk of suppression of endogenous melatonin levels Details Melatonin Acebutolol Sectral® An increased risk of suppression of endogenous melatonin levels Details Melatonin Betaxolol Betoptic S An increased risk of suppression of endogenous melatonin levels Details Melatonin Betaxolol Ophthalmic Betoptic® An increased risk of suppression of endogenous melatonin levels Details Melatonin Bisoprolol Zebeta® An increased risk of suppression of endogenous melatonin levels Details Melatonin Esmolol Brevibloc An increased risk of suppression of endogenous melatonin levels Details Melatonin Estradiol Delestrogen Increased melatonin exposure Details Melatonin Estradiol Topical Divigel Increased melatonin exposure Details Melatonin Estradiol Transdermal Patch Alora® Increased melatonin exposure Details Melatonin Ibuprofen Addaprin An increased risk of suppression of endogenous melatonin levels Details Melatonin Labetalol Normodyne® An increased risk of suppression of endogenous melatonin levels Details Melatonin Levobunolol Ophthalmic AKBeta® An increased risk of suppression of endogenous melatonin levels Details Melatonin Levonorgestrel After banger Increased melatonin exposure Details Melatonin Levonorgestrel Intrauterine System Kyleena Increased melatonin exposure Details Melatonin Medroxyprogesterone Amen® Increased melatonin exposure Details Melatonin Medroxyprogesterone Injection Depo-Provera Increased melatonin exposure Details Melatonin Nadolol Corgard An increased risk of suppression of endogenous melatonin levels Details Melatonin Nebivolol Bystolic An increased risk of suppression of endogenous melatonin levels Details Melatonin Penbutolol Levatol® An increased risk of suppression of endogenous melatonin levels Details

Minor

Melatonin Nifedipine Adalat® Increased blood pressure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.