Melperone

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Metoclopramide Nasal Spray Nalbuphine Injection Levodopa Oral Inhalation Cetirizine Injection Hydromorphone Injection
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Melperone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Melperone Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Melperone Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Melperone Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Melperone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Melperone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Melperone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Melperone Diazepam Rectal Diastat Increased risk of CNS depression Details Melperone Esketamine Nasal Spray Spravato Increased risk of sedation Details Melperone Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Melperone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Melperone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Melperone Hydroxychloroquine Plaquenil An increased risk of seizures Details Melperone Lacosamide Injection Motpoly An increased risk of CNS depression Details Melperone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Melperone Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Melperone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Melperone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Melperone Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Melperone Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Melperone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.