Melphalan Injection

140 interactions 460 cited references

Also sold as: Alkeran Alkeran® Injection Evomela Evomela® Injection Hepzato Ivra

About Melphalan Injection

Melphalan injection is used to treat multiple myeloma (a type of cancer of the bone marrow) in people who are unable to take melphalan by mouth. Melphalan injection is also used to destroy bone marrow and cancer cells in preparation for a bone marrow transplant in people with multiple myeloma. Melphalan is in a class o… Read the full Melphalan Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Typhoid Vaccine Varicella Virus Vaccine, Live Yellow Fever Vaccine Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

9 Contraindicated 129 Major 2 Moderate

All (140) Contraindicated (9) Major (129) Moderate (2)

Contraindicated

Melphalan Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Melphalan Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Melphalan Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Melphalan Injection Abciximab An increased risk of bleeding Details Melphalan Injection Aceclofenac An increased risk of bleeding Details Melphalan Injection Acemetacin An increased risk of bleeding Details Melphalan Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Melphalan Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Melphalan Injection Alfuzosin UroXatral An increased risk of severe hypotension Details Melphalan Injection Amlodipine Amvaz® An increased risk of severe hypotension Details Melphalan Injection Amtolmetin Guacil An increased risk of bleeding Details Melphalan Injection Anagrelide Agrylin An increased risk of bleeding Details Melphalan Injection Apixaban Eliquis An increased risk of bleeding Details Melphalan Injection Aranidipine An increased risk of severe hypotension Details Melphalan Injection Aspirin Acuprin® An increased risk of bleeding Details Melphalan Injection Benazepril Lotensin An increased risk of severe hypotension Details Melphalan Injection Bepridil An increased risk of severe hypotension Details Melphalan Injection Bromfenac Bromsite An increased risk of bleeding Details Melphalan Injection Bufexamac An increased risk of bleeding Details Melphalan Injection Bunazosin An increased risk of severe hypotension Details Melphalan Injection Captopril Capoten® An increased risk of severe hypotension Details Melphalan Injection Carmustine BiCNU An increased risk of lung toxicity Details Melphalan Injection Celecoxib Celebrex An increased risk of bleeding Details Melphalan Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Melphalan Injection Choline Salicylate An increased risk of bleeding Details Melphalan Injection Cilnidipine An increased risk of severe hypotension Details Melphalan Injection Cilostazol Pletal® An increased risk of bleeding Details Melphalan Injection Cisplatin Altered melphalan clearance Details Melphalan Injection Clevidipine An increased risk of severe hypotension Details Melphalan Injection Clonixin An increased risk of bleeding Details Melphalan Injection Clopidogrel Plavix An increased risk of bleeding Details Melphalan Injection Cyclosporine Atopica An increased risk of severe renal failure Details Melphalan Injection Dabigatran Etexilate An increased risk of bleeding Details Melphalan Injection Dapiprazole An increased risk of severe hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.