Melphalan

156 interactions 460 cited references
Also sold as: Alkeran Alkeran® Tablets Evomela Hepzato Ivra
About Melphalan

Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). Melphalan is in a class of medications called alkylating agents. It works by stopping or slowi… Read the full Melphalan drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Mumps Virus Vaccine, Live
9 Contraindicated 145 Major 2 Moderate
All (156) Contraindicated (9) Major (145) Moderate (2)

Major

Melphalan Mefenamic Acid Ponstel® An increased risk of bleeding Details Melphalan Meloxicam Alloxate An increased risk of bleeding Details Melphalan Meloxicam Injection Alloxate An increased risk of bleeding Details Melphalan Abciximab An increased risk of bleeding Details Melphalan Aceclofenac An increased risk of bleeding Details Melphalan Acemetacin An increased risk of bleeding Details Melphalan Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Melphalan Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Melphalan Amtolmetin Guacil An increased risk of bleeding Details Melphalan Aranidipine An increased risk of severe hypotension Details Melphalan Bepridil An increased risk of severe hypotension Details Melphalan Bromfenac Bromsite An increased risk of bleeding Details Melphalan Bufexamac An increased risk of bleeding Details Melphalan Bunazosin An increased risk of severe hypotension Details Melphalan Celecoxib Celebrex An increased risk of bleeding Details Melphalan Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Melphalan Choline Salicylate An increased risk of bleeding Details Melphalan Cilnidipine An increased risk of severe hypotension Details Melphalan Cilostazol Pletal® An increased risk of bleeding Details Melphalan Cisplatin Altered melphalan clearance Details Melphalan Clevidipine An increased risk of severe hypotension Details Melphalan Clonixin An increased risk of bleeding Details Melphalan Cyclosporine Atopica An increased risk of severe renal failure Details Melphalan Dapiprazole An increased risk of severe hypotension Details Melphalan Dexibuprofen An increased risk of bleeding Details Melphalan Dexketoprofen An increased risk of bleeding Details Melphalan Diclofenac Aleve Arthritis Pain An increased risk of bleeding Details Melphalan Diflunisal Dolobid An increased risk of bleeding Details Melphalan Diltiazem Cardizem An increased risk of severe hypotension Details Melphalan Dipyrone An increased risk of bleeding Details Melphalan Droxicam An increased risk of bleeding Details Melphalan Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Enalaprilat An increased risk of severe hypotension Details Melphalan Eptifibatide An increased risk of bleeding Details Melphalan Etofenamate An increased risk of bleeding Details Melphalan Etoricoxib An increased risk of bleeding Details Melphalan Felbinac An increased risk of bleeding Details Melphalan Fepradinol An increased risk of bleeding Details Melphalan Feprazone An increased risk of bleeding Details Melphalan Floctafenine An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.