Melphalan

156 interactions 460 cited references
Also sold as: Alkeran Alkeran® Tablets Evomela Hepzato Ivra
About Melphalan

Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). Melphalan is in a class of medications called alkylating agents. It works by stopping or slowi… Read the full Melphalan drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Mumps Virus Vaccine, Live
9 Contraindicated 145 Major 2 Moderate
All (156) Contraindicated (9) Major (145) Moderate (2)

Major

Melphalan Flufenamic Acid An increased risk of bleeding Details Melphalan Indomethacin Indocin An increased risk of bleeding Details Melphalan Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Lercanidipine An increased risk of severe hypotension Details Melphalan Lornoxicam An increased risk of bleeding Details Melphalan Loxoprofen An increased risk of bleeding Details Melphalan Lumiracoxib An increased risk of bleeding Details Melphalan Manidipine An increased risk of severe hypotension Details Melphalan Moexipril Univasc® An increased risk of severe hypotension Details Melphalan Morniflumate An increased risk of bleeding Details Melphalan Moxisylyte An increased risk of severe hypotension Details Melphalan Nabumetone Relafen An increased risk of bleeding Details Melphalan Naproxen Aleve An increased risk of bleeding Details Melphalan Nepafenac Ilevro An increased risk of bleeding Details Melphalan Nicardipine Cardene An increased risk of severe hypotension Details Melphalan Nifedipine Adalat® An increased risk of severe hypotension Details Melphalan Niflumic Acid An increased risk of bleeding Details Melphalan Nimesulide An increased risk of bleeding Details Melphalan Nimesulide Beta Cyclodextrin An increased risk of bleeding Details Melphalan Nimodipine Nimotop An increased risk of severe hypotension Details Melphalan Nisoldipine Sular An increased risk of severe hypotension Details Melphalan Nitrendipine An increased risk of severe hypotension Details Melphalan Oxaprozin Coxanto An increased risk of bleeding Details Melphalan Oxyphenbutazone An increased risk of bleeding Details Melphalan Parecoxib An increased risk of bleeding Details Melphalan Perindopril Aceon An increased risk of severe hypotension Details Melphalan Phenoxybenzamine Dibenzyline An increased risk of severe hypotension Details Melphalan Phentolamine An increased risk of severe hypotension Details Melphalan Phenylbutazone Equi-Phar An increased risk of bleeding Details Melphalan Piketoprofen An increased risk of bleeding Details Melphalan Piroxicam Feldene An increased risk of bleeding Details Melphalan Pranoprofen An increased risk of bleeding Details Melphalan Prasugrel Effient An increased risk of bleeding Details Melphalan Prazosin Minipress An increased risk of severe hypotension Details Melphalan Proglumetacin An increased risk of bleeding Details Melphalan Propyphenazone An increased risk of bleeding Details Melphalan Proquazone An increased risk of bleeding Details Melphalan Quinapril Accupril An increased risk of severe hypotension Details Melphalan Ramipril Altace An increased risk of severe hypotension Details Melphalan Rivaroxaban Xarelto An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.