Melphalan

156 interactions 460 cited references
Also sold as: Alkeran Alkeran® Tablets Evomela Hepzato Ivra
About Melphalan

Melphalan is used to treat multiple myeloma (a type of cancer of the bone marrow). Melphalan is also used to treat a certain type of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed). Melphalan is in a class of medications called alkylating agents. It works by stopping or slowi… Read the full Melphalan drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Mumps Virus Vaccine, Live
9 Contraindicated 145 Major 2 Moderate
All (156) Contraindicated (9) Major (145) Moderate (2)

Major

Melphalan Rofecoxib An increased risk of bleeding Details Melphalan Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Melphalan Salicylic Acid An increased risk of bleeding Details Melphalan Salsalate Disalcid An increased risk of bleeding Details Melphalan Silodosin Rapaflo An increased risk of severe hypotension Details Melphalan Sodium Salicylate An increased risk of bleeding Details Melphalan Sulfinpyrazone An increased risk of bleeding Details Melphalan Sulindac Clinoril® An increased risk of bleeding Details Melphalan Tamsulosin Flomax An increased risk of severe hypotension Details Melphalan Tenoxicam An increased risk of bleeding Details Melphalan Terazosin Hytrin® An increased risk of severe hypotension Details Melphalan Tiaprofenic Acid An increased risk of bleeding Details Melphalan Ticagrelor Brilinta An increased risk of bleeding Details Melphalan Ticlopidine Ticlid® An increased risk of bleeding Details Melphalan Tirofiban An increased risk of bleeding Details Melphalan Tolfenamic Acid An increased risk of bleeding Details Melphalan Tolmetin Tolectin 600 An increased risk of bleeding Details Melphalan Trandolapril Mavik® An increased risk of severe hypotension Details Melphalan Treprostinil Orenitram An increased risk of bleeding Details Melphalan Trimazosin An increased risk of severe hypotension Details Melphalan Urapidil An increased risk of severe hypotension Details Melphalan Valdecoxib An increased risk of bleeding Details Melphalan Verapamil Calan An increased risk of severe hypotension Details Melphalan Vorapaxar Zontivity An increased risk of bleeding Details Melphalan Warfarin Coumadin An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.