Meperidine

66 interactions 5 explained in plain English
Also sold as: Demerol
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Nalbuphine Injection Glycopyrronium Topical Palonosetron Injection Dolasetron Aripiprazole Injection
1 Contraindicated 59 Major 6 Moderate
All (66) Contraindicated (1) Major (59) Moderate (6)

Major

Meperidine Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Istradefylline Nourianz Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Ketoconazole Topical Extina® Foam Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Lacosamide Injection Motpoly An increased risk of CNS depression Details Meperidine Lefamulin Xenleta Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Lenacapavir Injection Sunlenca Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Lenacapavir Oral Sunlenca Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Letermovir Injection Prevymis Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Meperidine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Meperidine Midazolam Nasal Spray Nayzilam Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Midazolam Injection Nayzilam Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Meperidine Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Meperidine Nafcillin Injection Unipen® Injection Reduced meperidine exposure and reduced efficacy of meperidine Details Meperidine Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Meperidine Nevirapine Viramune Reduced meperidine exposure and reduced efficacy of meperidine Details Meperidine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.