Meperidine

66 interactions 5 explained in plain English
Also sold as: Demerol
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Meperidine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Meperidine Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Meperidine Sertraline Explained Increased risk of serotonin syndrome Details Meperidine Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Meperidine Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Aripiprazole Injection Abilify Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Asenapine Transdermal Patch Secuado Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Meperidine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Meperidine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Meperidine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Meperidine Clopidogrel Plavix Reduced efficacy of clopidogrel, an increased meperidine exposure and an increased risk of meperidine-related adverse effects Details Meperidine Clotrimazole Aardora Anti-Fungal Maximum Strength Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Clotrimazole Lozenge Mycelex® Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Clotrimazole Topical Cruex Antifungal Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Cyclosporine Injection Atopica Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Cyclosporine Ophthalmic Cequa Increased meperidine exposure and risk of increased or prolonged opioid effects Details Meperidine Dexamethasone Injection Decadron Reduced meperidine exposure and reduced efficacy of meperidine Details Meperidine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced meperidine exposure and reduced efficacy of meperidine Details Meperidine Diazepam Nasal Spray Valtoco Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Diazepam Rectal Diastat Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Meperidine Diphenhydramine Injection Banophen Increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Meperidine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Meperidine Disulfiram Antabuse Increased meperidine exposure and an increased risk of meperidine-related adverse effects Details Meperidine Dolasetron Anzemet Increased risk of serotonin syndrome Details Meperidine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Meperidine Enasidenib Idhifa Reduced meperidine exposure and reduced efficacy of meperidine Details Meperidine Esketamine Nasal Spray Spravato Increased risk of sedation Details Meperidine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Meperidine Furosemide Injection Disal Reduced efficacy of diuretics Details Meperidine Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Meperidine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Meperidine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Meperidine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Meperidine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.