Meperidine

Name: Meperidine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

66 interactions 5 explained in plain English

Also sold as: Demerol

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Nalbuphine Injection Glycopyrronium Topical Palonosetron Injection Dolasetron Aripiprazole Injection

1 Contraindicated 59 Major 6 Moderate

All (66) Contraindicated (1) Major (59) Moderate (6)

Moderate

Meperidine Acyclovir Avaclyr Increased meperidine and its metabolite normeperidine exposure Details Meperidine Acyclovir Injection Avaclyr Increased meperidine and its metabolite normeperidine exposure Details Meperidine Acyclovir Ophthalmic Avaclyr Increased meperidine and its metabolite normeperidine exposure Details Meperidine Acyclovir Topical Zovirax Increased meperidine and its metabolite normeperidine exposure Details Meperidine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Meperidine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.