Mestranol

48 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Hydrocortisone Colesevelam Nafcillin Injection Meropenem Injection Bexarotene Topical

41 Major 7 Moderate

All (48) Major (41) Moderate (7)

Major

Mestranol Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Mestranol Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Mestranol Ampicillin Amcill® Decreased contraceptive effectiveness Details Mestranol Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Mestranol Bexarotene Targretin Decreased contraceptive effectiveness Details Mestranol Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Mestranol Cefaclor Ceclor® Decreased contraceptive effectiveness Details Mestranol Cefadroxil Duricef® Decreased contraceptive effectiveness Details Mestranol Cefdinir Omnicef® Decreased contraceptive effectiveness Details Mestranol Cefixime Suprax Decreased contraceptive effectiveness Details Mestranol Cefprozil Cefzil® Decreased contraceptive effectiveness Details Mestranol Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Mestranol Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Mestranol Colesevelam Welchol Decreased contraceptive effectiveness Details Mestranol Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Mestranol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Mestranol Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Mestranol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Mestranol Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Mestranol Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Mestranol Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Mestranol Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Mestranol Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Mestranol Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Mestranol Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Mestranol Hydroxychloroquine Plaquenil An increased risk of seizures Details Mestranol Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Mestranol Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Mestranol Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Mestranol Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Mestranol Methylergonovine Methergine Increased methylergonovine exposure Details Mestranol Minocycline Amzeeq Decreased contraceptive efficacy Details Mestranol Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Mestranol Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Mestranol Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Mestranol Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Mestranol Nifedipine Adalat® Increased NIFEdipine exposure Details Mestranol Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Mestranol Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Mestranol Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details

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