Methacycline

19 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin V Potassium Penicillin G Benzathine Injection Nafcillin Injection Penicillin G Procaine Injection
1 Contraindicated 14 Major 4 Moderate
All (19) Contraindicated (1) Major (14) Moderate (4)

Contraindicated

Methacycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Methacycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Methacycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Methacycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Methacycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Methacycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Methacycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Methacycline Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Methacycline Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Methacycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methacycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methacycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Methacycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Methacycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Methacycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

Moderate

Methacycline Cholestyramine Resin Locholest® Decreased methacycline concentrations Details Methacycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Methacycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details Methacycline Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.