Methdilazine

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Metoclopramide Nasal Spray Levodopa Oral Inhalation Nalbuphine Injection Diazepam Rectal Cetirizine Injection
20 Major 2 Moderate
All (22) Major (20) Moderate (2)

Major

Methdilazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Methdilazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Methdilazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Methdilazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Methdilazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Methdilazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methdilazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methdilazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Methdilazine Diazepam Rectal Diastat Increased risk of CNS depression Details Methdilazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Methdilazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methdilazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Methdilazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Methdilazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Methdilazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Methdilazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Methdilazine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Methdilazine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Methdilazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methdilazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Methdilazine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Methdilazine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.