Methicillin

15 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Demeclocycline Doxycycline Injection Eravacycline Injection Hydroxychloroquine Levonorgestrel Levonorgestrel Intrauterine System
10 Major 5 Minor
All (15) Major (10) Minor (5)

Major

Methicillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Methicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Methicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Methicillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Methicillin Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Methicillin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Methicillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methicillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Methicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Minor

Methicillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Methicillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Methicillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Methicillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Methicillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.