Methohexital

27 interactions 3 explained in plain English
Also sold as: Brevital
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Methohexital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Methohexital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Methohexital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Methohexital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Methohexital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Methohexital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methohexital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methohexital Diazepam Nasal Spray Valtoco An increased risk of CNS and respiratory depression Details Methohexital Diazepam Rectal Diastat An increased risk of CNS and respiratory depression Details Methohexital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Methohexital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Methohexital Esketamine Nasal Spray Spravato Increased risk of sedation Details Methohexital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methohexital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Methohexital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Methohexital Lacosamide Injection Motpoly An increased risk of CNS depression Details Methohexital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Methohexital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Methohexital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Methohexital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Methohexital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Methohexital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Methohexital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Methohexital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methohexital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.