Methotrexate
420 interactions 996 cited referencesMethotrexate is an antimetabolite used to treat severe psoriasis, rheumatoid arthritis, and certain cancers. Read the full Methotrexate drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Methotrexate Azathioprine Azasan An increased risk of hepatotoxicity Details Methotrexate Cholestyramine Resin Locholest® Decreased methotrexate effectiveness Details Methotrexate Encorafenib Braftovi Increased methotrexate exposure and an increased risk of methotrexate-related toxicities Details Methotrexate Cholestyramine Prevalite Decreased methotrexate effectiveness Details Methotrexate Etoricoxib Increased methotrexate plasma concentrations and toxicity Details Methotrexate L-Methylfolate Decreased methotrexate and/or l-methylfolate efficacy Details Methotrexate Oteseconazole Increased exposure to BCRP substrates Details Methotrexate Procarbazine Renal dysfunction Details Methotrexate Rolapitant Varubi Increased methotrexate exposure Details Methotrexate Sars-Cov-2 (Covid-19) Vaccine, Adenovirus 26 Vector (Janssen) Decreased immune response to COVID-19 vaccine Details Methotrexate Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Decreased immune response to COVID-19 vaccine Details Methotrexate Sars-Cov-2 (Covid-19) Vaccine, Mrna (Pfizer) Decreased immune response to COVID-19 vaccine Details Methotrexate Theophylline Accurbron® Increased theophylline exposure Details Methotrexate Zongertinib Hernexeos Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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